Pygaba 75 Dosage/Direction for Use

The dose range is 150 to 600 mg per day given orally in 2 or 3 divided doses.
Neuropathic pain: Pregabalin treatment can be started at a dose of 150 mg per day. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg per day after an additional 7-day interval.
Epilepsy: Pregabalin treatment can be started with a dose of 150 mg per day. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day after 1 week. The maximum dosage of 600 mg per day may be achieved after an additional week.
Generalized Anxiety Disorder: The dosage range is 150 to 600 mg per day given as two or three divided doses. The need for treatment should be reassessed regularly.
Pregabalin treatment can be started with a dose of 150 mg per day. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day after 1 week. Following an additional week the dosage may be increased to 450 mg per day. The maximum dosage of 600 mg per day may be achieved after additional week.
Fibromyalgia: The usual dose range for most patients is 300 to 450 mg per day given in two divided doses. Some patients may derive additional benefit at 600 mg per day. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). If needed, in some patients, based on individual response and tolerability, the dose may be increased to maximum dosage of 600 mg/day after an additional week.
Discontinuation of therapy: When discontinuing pregabalin, taper off gradually over at least 1 week.
Special Population: Renal impairment: In patients with renal function impairment, dosage adjustment should be based on creatinine clearance (CrCl), as indicated in the following Table 1 determined using the Cockcroft-Gault formula, the formula show below. (See Equation.)

Click on icon to see table/diagram/image

For patients undergoing hemodialysis, the pregabalin daily dose should be adjusted based on renal function, a supplementary dose should be given immediately following every 4-hour hemodialysis treatment. (See Table 1.)

Click on icon to see table/diagram/image

Hepatic impairment: No dosage adjustment is required for patients with hepatic impairment.
Children: The safety and efficacy of pregabalin in children have not been established.
Elderly: Elderly patients may require a dose reduction of pregabalin due to a decreased renal function.
Method of Administration: Pregabalin is for oral use only and may be taken with or without food.